Etiological and Prospective Family Study in Southwestern Pennsylvania, Baseline Data

Study Overview


The Center for Education and Drug Abuse Research (CEDAR) conducts research on 775 families enrolled in the Center's prospective investigations into the etiology of substance use disorder (SUD). The pro-bands are men with lifetime presence/absence of SUD consequent to use of an illicit drug who have a 10-12 year old biological son or daughter. CEDAR has already shown that they can predict in 10-12 year old youth cannabis use disorder by age 22 with approximately 70 percent accuracy, thereby substantiating the paradigm, subject recruitment strategy, and measurement protocols. Multidisciplinary research is conducted on family members (father, mother, children) with the objective of elucidating the genetic, bio-behavioral, and environmental factors on development of SUD consequent to use of illegal drugs. Research protocols are organized into three thematically connected research modules (Neurogenetics, Developmental Psychopathology, and Translation) linking etiology and prevention. The research components thus align with the NIH Roadmap model such that basic science informs clinical research leading to prevention guided by an understanding of etiology. In addition to module-level research, faculty also participate in three organizational aims: (1) Devise a practical scale to quantify the transmissible liability to SUD; (2) Empirically test a bio-psychological theory of SUD etiology focusing on off-time maturation leading to psychological dysregulation predisposing to SUD; and, (3) Delineate SUD liability variants within an ontogenetic framework.

Study Author(s): 
Sampling Procedures: 

Three different samples were recruited for this study. First, an assessment of fathers of 10 to 12 year olds was conducted to determine their substance use disease (SUD). Children of fathers with SUD were recruited into the high risk group (N = 344), children of fathers without SUD were recruited into the low risk group (N = 350). An additional 81 children of fathers with psychiatric disorders but not SUD were recruited as a third group.

Contact and Data Access

1. I will use the dataset solely for statistical analysis and reporting of aggregated information and not for investigation of a specific individual or organization. 2. I will produce no links among the Distributors' datasets or among the Distributor's data and other datasets that could identify individuals or organizations. 3. I represent neither I, nor anyone I know, has any prior knowledge of the possible identification of any study participants in any dataset that I am being licensed to use. 4. I will not knowingly divulge any information that could be used to identify individual participants in the study, nor will I attempt to identify or contact any study participant and I agree to use any precautions necessary to prevent such identification. 5. I will not reproduce the dataset except as it is necessary for scholarly purposes. I will destroy the dataset upon completion of my scholarly work with it. 6. I will not share data from the dataset (in any form or by any means) with any third party, as I understand that all users of the data must obtain it directly from the distributor. 7. I will make appropriate acknowledgement of the contributor and distributor of the dataset in any manuscript or publication. 8. The distributor makes no warranties, express or implied, by operation of law or otherwise regarding or relating to the dataset.
The original collector of the data, SSRI, and the relevant funding agencies, bear no responsibility for the use of the data or for interpretations and inferences based upon such users.

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